Cannabis induced cell death in leukemic cells 1

Cannabis induced cell death in leukemic cells

Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway Thomas Powles, Robert te Poele, Jonathan Shamash, Tracy Chaplin, David Propper, Simon Joel, Tim Oliver and Wai Man Liu Blood 2005 105:1214-1221; doi: https://doi.org/10.1182/blood-2004-03-1182 Abstract Δ9-Tetrahydrocannabinol (THC) is the active metabolite of cannabis. THC causes cell death in vitro through the activation of complex signal transduction pathways. However, the role that the cannabinoid 1 and 2 receptors (CB1-R and CB2-R) play in this …